Friday, June 27, 2008

Psychotic Disease Information


Psychotic disorders include severe mental disorders which are characterized by extreme impairment of a person's ability to think clearly, respond emotionally, communicate effectively, understand reality, and behave appropriately. Psychotic symptoms can be seen in teenagers with a number of serious mental illnesses, such as depression, bi-polar disorder (manic-depression), schizophrenia, and with some forms of alcohol and drug abuse. Psychotic symptoms interfere with a person’s daily functioning and can be quite debilitating. Psychotic symptoms include delusions and hallucinations.

Delusion: A false, fixed, odd, or unusual belief firmly held by the patient. The belief is not ordinarily accepted by other members of the person’s culture or subculture. There are delusions of paranoia (others are plotting against them), grandiose delusions (exaggerated ideas of one's importance or identity), and somatic delusions (a healthy person believing that he/she has a terminal illness).

Hallucination: A sensory perception (seeing, hearing, feeling, and smelling) in the absence of an outside stimulus. For example, with auditory hallucinations, the person hears voices when there is no one talking.

Schizophrenia Disease Information


Schizophrenia is a chronic, severe, and disabling brain disorder that has been recognized throughout recorded history. It affects about 1 percent of Americans.1

People with schizophrenia may hear voices other people don't hear or they may believe that others are reading their minds, controlling their thoughts, or plotting to harm them. These experiences are terrifying and can cause fearfulness, withdrawal, or extreme agitation. People with schizophrenia may not make sense when they talk, may sit for hours without moving or talking much, or may seem perfectly fine until they talk about what they are really thinking. Because many people with schizophrenia have difficulty holding a job or caring for themselves, the burden on their families and society is significant as well.

Available treatments can relieve many of the disorder's symptoms, but most people who have schizophrenia must cope with some residual symptoms as long as they live. Nevertheless, this is a time of hope for people with schizophrenia and their families. Many people with the disorder now lead rewarding and meaningful lives in their communities. Researchers are developing more effective medications and using new research tools to understand the causes of schizophrenia and to find ways to prevent and treat it.

This brochure presents information on the symptoms of schizophrenia, when the symptoms appear, how the disease develops, current treatments, support for patients and their loved ones, and new directions in research.

What are the symptoms of schizophrenia?

The symptoms of schizophrenia fall into three broad categories:
Positive symptomsare unusual thoughts or perceptions, including hallucinations, delusions, thought disorder, and disorders of movement.
Negative symptomsrepresent a loss or a decrease in the ability to initiate plans, speak, express emotion, or find pleasure in everyday life. These symptoms are harder to recognize as part of the disorder and can be mistaken for laziness or depression.
Cognitive symptoms(or cognitive deficits) are problems with attention, certain types of memory, and the executive functions that allow us to plan and organize. Cognitive deficits can also be difficult to recognize as part of the disorder but are the most disabling in terms of leading a normal life.
Positive symptoms

Positive symptoms are easy-to-spot behaviors not seen in healthy people and usually involve a loss of contact with reality. They include hallucinations, delusions, thought disorder, and disorders of movement. Positive symptoms can come and go. Sometimes they are severe and at other times hardly noticeable, depending on whether the individual is receiving treatment.

Hallucinations.A hallucination is something a person sees, hears, smells, or feels that no one else can see, hear, smell, or feel. "Voices" are the most common type of hallucination in schizophrenia. Many people with the disorder hear voices that may comment on their behavior, order them to do things, warn them of impending danger, or talk to each other (usually about the patient). They may hear these voices for a long time before family and friends notice that something is wrong. Other types of hallucinations include seeing people or objects that are not there, smelling odors that no one else detects (although this can also be a symptom of certain brain tumors), and feeling things like invisible fingers touching their bodies when no one is near.

Delusions.Delusions are false personal beliefs that are not part of the person's culture and do not change, even when other people present proof that the beliefs are not true or logical. People with schizophrenia can have delusions that are quite bizarre, such as believing that neighbors can control their behavior with magnetic waves, people on television are directing special messages to them, or radio stations are broadcasting their thoughts aloud to others. They may also have delusions of grandeur and think they are famous historical figures. People with paranoid schizophrenia can believe that others are deliberately cheating, harassing, poisoning, spying upon, or plotting against them or the people they care about. These beliefs are called delusions of persecution.

Thought Disorder.People with schizophrenia often have unusual thought processes. One dramatic form is disorganized thinking, in which the person has difficulty organizing his or her thoughts or connecting them logically. Speech may be garbled or hard to understand. Another form is "thought blocking," in which the person stops abruptly in the middle of a thought. When asked why, the person may say that it felt as if the thought had been taken out of his or her head. Finally, the individual might make up unintelligible words, or "neologisms."

Disorders of Movement.People with schizophrenia can be clumsy and uncoordinated. They may also exhibit involuntary movements and may grimace or exhibit unusual mannerisms. They may repeat certain motions over and over or, in extreme cases, may become catatonic. Catatonia is a state of immobility and unresponsiveness. It was more common when treatment for schizophrenia was not available; fortunately, it is now rare.2
Negative symptoms

The term "negative symptoms" refers to reductions in normal emotional and behavioral states. These include the following:
flat affect (immobile facial expression, monotonous voice),
lack of pleasure in everyday life,
diminished ability to initiate and sustain planned activity, and
speaking infrequently, even when forced to interact.

People with schizophrenia often neglect basic hygiene and need help with everyday activities. Because it is not as obvious that negative symptoms are part of a psychiatric illness, people with schizophrenia are often perceived as lazy and unwilling to better their lives.
Cognitive symptoms

Cognitive symptoms are subtle and are often detected only when neuropsychological tests are performed. They include the following:
poor "executive functioning" (the ability to absorb and interpret information and make decisions based on that information),
inability to sustain attention, and
problems with "working memory" (the ability to keep recently learned information in mind and use it right away)

Cognitive impairments often interfere with the patient's ability to lead a normal life and earn a living. They can cause great emotional distress.

When does it start and who gets it?
Psychotic symptoms (such as hallucinations and delusions) usually emerge in men in their late teens and early 20s and in women in their mid-20s to early 30s. They seldom occur after age 45 and only rarely before puberty, although cases of schizophrenia in children as young as 5 have been reported. In adolescents, the first signs can include a change of friends, a drop in grades, sleep problems, and irritability. Because many normal adolescents exhibit these behaviors as well, a diagnosis can be difficult to make at this stage. In young people who go on to develop the disease, this is called the "prodromal" period.

Research has shown that schizophrenia affects men and women equally and occurs at similar rates in all ethnic groups around the world.3

Are people with schizophrenia violent?
People with schizophrenia are not especially prone to violence and often prefer to be left alone. Studies show that if people have no record of criminal violence before they develop schizophrenia and are not substance abusers, they are unlikely to commit crimes after they become ill. Most violent crimes are not committed by people with schizophrenia, and most people with schizophrenia do not commit violent crimes. Substance abuse always increases violent behavior, regardless of the presence of schizophrenia (see sidebar). If someone with paranoid schizophrenia becomes violent, the violence is most often directed at family members and takes place at home.

What about suicide?
People with schizophrenia attempt suicide much more often than people in the general population. About 104 5 percent (especially young adult males) succeed. It is hard to predict which people with schizophrenia are prone to suicide, so if someone talks about or tries to commit suicide, professional help should be sought right away.

What causes schizophrenia?
Substance abuse

Some people who abuse drugs show symptoms similar to those of schizophrenia, and people with schizophrenia may be mistaken for people who are high on drugs. While most researchers do not believe that substance abuse causes schizophrenia, people who have schizophrenia abuse alcohol and/or drugs more often than the general population.

Substance abuse can reduce the effectiveness of treatment for schizophrenia. Stimulants (such as amphetamines or cocaine), PCP, and marijuana may make the symptoms of schizophrenia worse, and substance abuse also makes it more likely that patients will not follow their treatment plan.
Schizophrenia and Nicotine

The most common form of substance abuse in people with schizophrenia is an addiction to nicotine. People with schizophrenia are addicted to nicotine at three times the rate of the general population (75–90 percent vs. 25–30 percent).6

Research has revealed that the relationship between smoking and schizophrenia is complex. People with schizophrenia seem to be driven to smoke, and researchers are exploring whether there is a biological basis for this need. In addition to its known health hazards, several studies have found that smoking interferes with the action of antipsychotic drugs. People with schizophrenia who smoke may need higher doses of their medication.

Quitting smoking may be especially difficult for people with schizophrenia since nicotine withdrawal may cause their psychotic symptoms to temporarily get worse. Smoking cessation strategies that include nicotine replacement methods may be better tolerated. Doctors who treat people with schizophrenia should carefully monitor their patient's response to antipsychotic medication if the patient decides to either start or stop smoking.

Like many other illnesses, schizophrenia is believed to result from a combination of environmental and genetic factors. All the tools of modern science are being used to search for the causes of this disorder.

Can schizophrenia be inherited?

Scientists have long known that schizophrenia runs in families. It occurs in 1 percent of the general population but is seen in 10 percent of people with a first-degree relative (a parent, brother, or sister) with the disorder. People who have second-degree relatives (aunts, uncles, grandparents, or cousins) with the disease also develop schizophrenia more often than the general population. The identical twin of a person with schizophrenia is most at risk, with a 40 to 65 percent chance of developing the disorder.7

Our genes are located on 23 pairs of chromosomes that are found in each cell. We inherit two copies of each gene, one from each parent. Several of these genes are thought to be associated with an increased risk of schizophrenia, but scientists believe that each gene has a very small effect and is not responsible for causing the disease by itself. It is still not possible to predict who will develop the disease by looking at genetic material.

Although there is a genetic risk for schizophrenia, it is not likely that genes alone are sufficient to cause the disorder. Interactions between genes and the environment are thought to be necessary for schizophrenia to develop. Many environmental factors have been suggested as risk factors, such as exposure to viruses or malnutrition in the womb, problems during birth, and psychosocial factors, like stressful environmental conditions.

Do people with schizophrenia have faulty brain chemistry?

It is likely that an imbalance in the complex, interrelated chemical reactions of the brain involving the neurotransmitters dopamine and glutamate (and possibly others) plays a role in schizophrenia. Neurotransmitters are substances that allow brain cells to communicate with one another. Basic knowledge about brain chemistry and its link to schizophrenia is expanding rapidly and is a promising area of research.

Do the brains of people with schizophrenia look different?

The brains of people with schizophrenia look a little different than the brains of healthy people, but the differences are small. Sometimes the fluid-filled cavities at the center of the brain, called ventricles, are larger in people with schizophrenia; overall gray matter volume is lower; and some areas of the brain have less or more metabolic activity.3 Microscopic studies of brain tissue after death have also revealed small changes in the distribution or characteristics of brain cells in people with schizophrenia. It appears that many of these changes were prenatal because they are not accompanied by glial cells, which are always present when a brain injury occurs after birth.3 One theory suggests that problems during brain development lead to faulty connections that lie dormant until puberty. The brain undergoes major changes during puberty, and these changes could trigger psychotic symptoms.

The only way to answer these questions is to conduct more research. Scientists in the United States and around the world are studying schizophrenia and trying to develop new ways to prevent and treat the disorder.
How is schizophrenia treated?
Because the causes of schizophrenia are still unknown, current treatments focus on eliminating the symptoms of the disease.
Antipsychotic medications

Antipsychotic medications have been available since the mid-1950s. They effectively alleviate the positive symptoms of schizophrenia. While these drugs have greatly improved the lives of many patients, they do not cure schizophrenia.

Everyone responds differently to antipsychotic medication. Sometimes several different drugs must be tried before the right one is found. People with schizophrenia should work in partnership with their doctors to find the medications that control their symptoms best with the fewest side effects.

The older antipsychotic medications include chlorpromazine (Thorazine®), haloperidol (Haldol®), perphenazine (Etrafon®, Trilafon®), and fluphenzine (Prolixin®). The older medications can cause extrapyramidal side effects, such as rigidity, persistent muscle spasms, tremors, and restlessness.

In the 1990s, new drugs, called atypical antipsychotics, were developed that rarely produced these side effects. The first of these new drugs was clozapine (Clozaril®). It treats psychotic symptoms effectively even in people who do not respond to other medications, but it can produce a serious problem called agranulocytosis, a loss of the white blood cells that fight infection. Therefore, patients who take clozapine must have their white blood cell counts monitored every week or two. The inconvenience and cost of both the blood tests and the medication itself has made treatment with clozapine difficult for many people, but it is the drug of choice for those whose symptoms do not respond to the other antipsychotic medications, old or new.

Some of the drugs that were developed after clozapine was introduced—such as risperidone (Risperdal®), olanzapine (Zyprexa®), quietiapine (Seroquel®), sertindole (Serdolect®), and ziprasidone (Geodon®)—are effective and rarely produce extrapyramidal symptoms and do not cause agranulocytosis; but they can cause weight gain and metabolic changes associated with an increased risk of diabetes and high cholesterol.8

People respond individually to antipsychotic medications, although agitation and hallucinations usually improve within days and delusions usually improve within a few weeks. Many people see substantial improvement in both types of symptoms by the sixth week of treatment. No one can tell beforehand exactly how a medication will affect a particular individual, and sometimes several medications must be tried before the right one is found.

When people first start to take atypical antipsychotics, they may become drowsy; experience dizziness when they change positions; have blurred vision; or develop a rapid heartbeat, menstrual problems, a sensitivity to the sun, or skin rashes. Many of these symptoms will go away after the first days of treatment, but people who are taking atypical antipsychotics should not drive until they adjust to their new medication.

If people with schizophrenia become depressed, it may be necessary to add an antidepressant to their drug regimen.

A large clinical trial funded by the National Institute of Mental Health (NIMH), known as CATIE (Clinical Antipsychotic Trials of Intervention Effectiveness), compared the effectiveness and side effects of five antipsychotic medications—both new and older antipsychotics—that are used to treat people with schizophrenia. For more information, visit the NIMH CATIE page.

Length of Treatment. Like diabetes or high blood pressure, schizophrenia is a chronic disorder that needs constant management. At the moment, it cannot be cured, but the rate of recurrence of psychotic episodes can be decreased significantly by staying on medication. Although responses vary from person to person, most people with schizophrenia need to take some type of medication for the rest of their lives as well as use other approaches, such as supportive therapy or rehabilitation.

Relapses occur most often when people with schizophrenia stop taking their antipsychotic medication because they feel better, or only take it occasionally because they forget or don't think taking it regularly is important. It is very important for people with schizophrenia to take their medication on a regular basis and for as long as their doctors recommend. If they do so, they will experience fewer psychotic symptoms.

No antipsychotic medication should be discontinued without talking to the doctor who prescribed it, and it should always be tapered off under a doctor's supervision rather than being stopped all at once.

There are a variety of reasons why people with schizophrenia do not adhere to treatment. If they don't believe they are ill, they may not think they need medication at all. If their thinking is too disorganized, they may not remember to take their medication every day. If they don't like the side effects of one medication, they may stop taking it without trying a different medication. Substance abuse can also interfere with treatment effectiveness. Doctors should ask patients how often they take their medication and be sensitive to a patient's request to change dosages or to try new medications to eliminate unwelcome side effects.

There are many strategies to help people with schizophrenia take their drugs regularly. Some medications are available in long-acting, injectable forms, which eliminate the need to take a pill every day. Medication calendars or pillboxes labeled with the days of the week can both help patients remember to take their medications and let caregivers know whether medication has been taken. Electronic timers on clocks or watches can be programmed to beep when people need to take their pills, and pairing medication with routine daily events, like meals, can help patients adhere to dosing schedules.

Medication Interactions. Antipsychotic medications can produce unpleasant or dangerous side effects when taken with certain other drugs. For this reason, the doctor who prescribes the antipsychotics should be told about all medications (over-the-counter and prescription) and all vitamins, minerals, and herbal supplements the patient takes. Alcohol or other drug use should also be discussed.
Psychosocial treatment

Numerous studies have found that psychosocial treatments can help patients who are already stabilized on antipsychotic medications deal with certain aspects of schizophrenia, such as difficulty with communication, motivation, self-care, work, and establishing and maintaining relationships with others. Learning and using coping mechanisms to address these problems allows people with schizophrenia to attend school, work, and socialize. Patients who receive regular psychosocial treatment also adhere better to their medication schedule and have fewer relapses and hospitalizations. A positive relationship with a therapist or a case manager gives the patient a reliable source of information, sympathy, encouragement, and hope, all of which are essential for for managing the disease. The therapist can help patients better understand and adjust to living with schizophrenia by educating them about the causes of the disorder, common symptoms or problems they may experience, and the importance of staying on medications.

Illness Management Skills. People with schizophrenia can take an active role in managing their own illness. Once they learn basic facts about schizophrenia and the principles of schizophrenia treatment, they can make informed decisions about their care. If they are taught how to monitor the early warning signs of relapse and make a plan to respond to these signs, they can learn to prevent relapses. Patients can also be taught more effective coping skills to deal with persistent symptoms.

Integrated Treatment for Co-occurring Substance Abuse. Substance abuse is the most common co-occurring disorder in people with schizophrenia, but ordinary substance abuse treatment programs usually do not address this population's special needs. Integrating schizophrenia treatment programs and drug treatment programs produces better outcomes.

Rehabilitation. Rehabilitation emphasizes social and vocational training to help people with schizophrenia function more effectively in their communities. Because people with schizophrenia frequently become ill during the critical career-forming years of life (ages 18 to 35) and because the disease often interferes with normal cognitive functioning, most patients do not receive the training required for skilled work. Rehabilitation programs can include vocational counseling, job training, money management counseling, assistance in learning to use public transportation, and opportunities to practice social and workplace communication skills.

Family Education. Patients with schizophrenia are often discharged from the hospital into the care of their families, so it is important that family members know as much as possible about the disease to prevent relapses. Family members should be able to use different kinds of treatment adherence programs and have an arsenal of coping strategies and problem-solving skills to manage their ill relative effectively. Knowing where to find outpatient and family services that support people with schizophrenia and their caregivers is also valuable.

Cognitive Behavioral Therapy. Cognitive behavioral therapy is useful for patients with symptoms that persist even when they take medication. The cognitive therapist teaches people with schizophrenia how to test the reality of their thoughts and perceptions, how to "not listen" to their voices, and how to shake off the apathy that often immobilizes them. This treatment appears to be effective in reducing the severity of symptoms and decreasing the risk of relapse.

Self-Help Groups. Self-help groups for people with schizophrenia and their families are becoming increasingly common. Although professional therapists are not involved, the group members are a continuing source of mutual support and comfort for each other, which is also therapeutic. People in self-help groups know that others are facing the same problems they face and no longer feel isolated by their illness or the illness of their loved one. The networking that takes place in self-help groups can also generate social action. Families working together can advocate for research and more hospital and community treatment programs, and patients acting as a group may be able to draw public attention to the discriminations many people with mental illnesses still face in today's world.

Support groups and advocacy groups are excellent resources for people with many types of mental disorders.
What is the role of the patient’s support system?
Support for those with mental disorders can come from families, professional residential or day program caregivers, shelter operators, friends or roommates, professional case managers, or others in their communities or places of worship who are concerned about their welfare. There are many situations in which people with schizophrenia will need help from other people.

Getting Treatment. People with schizophrenia often resist treatment, believing that their delusions or hallucinations are real and psychiatric help is not required. If a crisis occurs, family and friends may need to take action to keep their loved one safe.

The issue of civil rights enters into any attempt to provide treatment. Laws protecting patients from involuntary commitment have become very strict, and trying to get help for someone who is mentally ill can be frustrating. These laws vary from state to state, but, generally, when people are dangerous to themselves or others because of mental illness and refuse to seek treatment, family members or friends may have to call the police to transport them to the hospital. In the emergency room, a mental health professional will assess the patient and determine whether a voluntary or involuntary admission is needed.

A person with mental illness who does not want treatment may hide strange behavior or ideas from a professional; therefore, family members and friends should ask to speak privately with the person conducting the patient's examination and explain what has been happening at home. The professional will then be able to question the patient and hear the patient's distorted thinking for themselves. Professionals must personally witness bizarre behavior and hear delusional thoughts before they can legally recommend commitment, and family and friends can give them the information they need to do so.

Caregiving. Ensuring that people with schizophrenia continue to get treatment and take their medication after they leave the hospital is also important. If patients stop taking their medication or stop going for follow-up appointments, their psychotic symptoms will return. If these symptoms become severe, they may become unable to care for their own basic needs for food, clothing, and shelter; they may neglect personal hygiene; and they may end up on the street or in jail, where they rarely receive the kind of help they need.

Family and friends can also help patients set realistic goals and regain their ability to function in the world. Each step toward these goals should be small enough to be attainable, and the patient should pursue them in an atmosphere of support. People with a mental illness who are pressured and criticized usually regress and their symptoms worsen. Telling them what they are doing right is the best way to help them move forward.

How should you respond when someone with schizophrenia makes statements that are strange or clearly false? Because these bizarre beliefs or hallucinations are real to the patient, it will not be useful to say they are wrong or imaginary. Going along with the delusions will not be helpful, either. It is best to calmly say that you see things differently than the patient does but that you acknowledge that everyone has the right to see things in his or her own way. Being respectful, supportive, and kind without tolerating dangerous or inappropriate behavior is the most helpful way to approach people with this disorder.
What is the outlook for the future?
The outlook for people with schizophrenia has improved over the last 30 years or so. Although there still is no cure, effective treatments have been developed, and many people with schizophrenia improve enough to lead independent, satisfying lives.

This is an exciting time for schizophrenia research. The explosion of knowledge in genetics, neuroscience, and behavioral research will enable a better understanding of the causes of the disorder, how to prevent it, and how to develop better treatments to allow those with schizophrenia to achieve their full potential.
How can a person participate in schizophrenia research?
Scientists worldwide are studying schizophrenia so they will be able to develop new ways to prevent and treat the disorder. The only way it can be understood is for researchers to study the illness as it presents itself in those who suffer from it. There are many different kinds of studies. Some studies require that medication be changed; others, like genetic studies, require no change at all in medications.

To receive information about federally and privately supported schizophrenia research, go to ClinicalTrials.gov. The information provided should be used in conjunction with advice from your health care professional.

NIMH conducts a Schizophrenia Research Program, which is located at the National Institute of Mental Health in Bethesda, Maryland. Travel assistance and study compensation are available for some studies. A list of outpatient and inpatient studies conducted at NIMH can be found at http://patientinfo.nimh.nih.gov. In addition, NIMH staff members can speak with you to help you determine whether their current studies are suitable for you or your family member. Simply call the toll free line at 1-888-674-6464. You can also indicate your interest in research participation by sending an email to Schizophrenia@intra.nimh.nih.gov. All calls remain confidential.
For more information

MedlinePlus, a service of the U.S. National Library of Medicine and the National Institutes of Health, provides updated information and resource lists for many health topics, including schizophrenia. It also lists mental health organizations that provide useful information. If you have Internet access, search for schizophrenia at: http://medlineplus.gov. En EspaƱol http://medlineplus.gov/spanish/


Information from NIMH is available in multiple formats. You can browse online, download documents in PDF, and order paper brochures through the mail. If you would like to have NIMH publications, you can order them online at www.nimh.nih.gov. If you do not have Internet access, please contact the NIMH Information Center at the numbers listed below.
National Institute of Mental Health
Public Information and Communications Branch
6001 Executive Boulevard
Room 8184, MSC 9663
Bethesda, MD 20892-9663
Phone: 301-443-4513, 1-866-615-NIMH (6464) toll-free
TTY: 1-866-415-8051 toll free
Fax: 301-443-4279
E-mail: nimhinfo@nih.gov
website: http://www.nimh.nih.gov

Addendum to Schizophrenia January 2007

Aripiprazole (Abilify) is another atypical antipsychotic medication used to treat the symptoms of schizophrenia and manic or mixed (manic and depressive) episodes of bipolar I disorder. Aripiprazole is in tablet and liquid form. An injectable form is used in the treatment of symptoms of agitation in schizophrenia and manic or mixed episodes of bipolar I disorder.

References
Regier DA, Narrow WE, Rae DS, Manderscheid RW, Locke BZ, Goodwin FK. The de facto US mental and addictive disorders service system. Epidemiologic catchment area prospective 1-year prevalence rates of disorders and services. Arch Gen Psychiatry. 1993 Feb;50(2):85-94.
Catatonic Schizophrenia. (1992). The ICD-10 Classification of Mental and Behavioural Disorders: Clinical descriptions and diagnostic guidelines. Geneva, Switzerland: World Health Organization.
Mueser KT, McGurk SR. Schizophrenia. Lancet. 2004 Jun 19;363(9426):2063-72.
Meltzer HY, Alphs L, Green AI, Altamura AC, Anand R, Bertoldi A, Bourgeois M, Chouinard G, Islam MZ, Kane J, Krishnan R, Lindenmayer JP, Potkin S; International Suicide Prevention Trial Study Group. Clozapine treatment for suicidality in schizophrenia: International Suicide Prevention Trial (InterSePT). Arch Gen Psychiatry. 2003 Jan;60(1):82-91.
Meltzer HY, Baldessarini RJ. Reducing the risk for suicide in schizophrenia and affective disorders. J Clin Psychiatry. 2003 Sep;64(9):1122-9.
Jones RT & Benowitz NL. (2002).Therapeutics for Nicotine Addiction. In Davis KL, Charney D, Coyle JT & Nemeroff C (Eds.), Neuropsychopharmacology: The Fifth Generation of Progress (pp1533-1544). Nashville, TN:American College of Neuropsychopharmacology.
Cardno AG, Gottesman II. Twin studies of schizophrenia: from bow-and-arrow concordances to star wars Mx and functional genomics. Am J Med Genet. 2000 Spring; 97(1):12-7.
Lieberman JA, Stroup TS, McEvoy JP, Swartz MS, Rosenheck RA, Perkins DO, Keefe RS, Davis SM, Davis CE, Lebowitz BD, Severe J, Hsiao JK; Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE). Effectiveness of antipsychotic drugs in patients with chronic schizophrenia. N Engl J Med. 2005 Sep 22;353(12):1209-23.

Asperger's Disease Information


History

Asperger's Disorder was first described in the 1940s by Viennese pediatrician Hans Asperger who observed autistic-like behaviors and difficulties with social and communication skills in boys who had normal intelligence and language development. Many professionals felt Asperger's Disorder was simply a milder form of autism and used the term "high-functioning autism" to describe these individuals. Professor Uta Frith, with the Institute of Cognitive Neuroscience of University College London and author of Autism and Asperger Syndrome, describes individuals with Asperger's Disorder as "having a dash of Autism." Asperger's Disorder was added to the American Psychiatric Association's Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) in 1994 as a separate disorder from autism. However, there are still many professionals who consider Asperger's Disorder a less severe form of autism.

Characteristics

What distinguishes Asperger's Disorder from Autism Disorder is the severity of the symptoms and the absence of language delays. Children with Asperger's Disorder may be only mildly affected and frequently have good language and cognitive skills. To the untrained observer, a child with Asperger's Disorder may just seem like a normal child behaving differently.

Children with autism are frequently seen as aloof and uninterested in others. This is not the case with Asperger's Disorder. Individuals with Asperger's Disorder usually want to fit in and have interaction with others; they simply don't know how to do it. They may be socially awkward, not understanding of conventional social rules, or show a lack of empathy. They may have limited eye contact, seem to be unengaged in a conversation, and not understand the use of gestures.

Interests in a particular subject may border on the obsessive. Children with Asperger's Disorder frequently like to collect categories of things, such as rocks or bottle caps. They may be proficient in knowing categories of information, such as baseball statistics or Latin names of flowers. While they may have good rote memory skills, they have difficulty with abstract concepts.

One of the major differences between Asperger's Disorder and autism is that, by definition, there is no speech delay in Asperger's. In fact, children with Asperger's Disorder frequently have good language skills; they simply use language in different ways. Speech patterns may be unusual, lack inflection or have a rhythmic nature, or it may be formal, but too loud or high pitched. Children with Asperger's Disorder may not understand the subtleties of language, such as irony and humor, or they may not understand the give-and- take nature of a conversation.

Another distinction between Asperger's Disorder and autism concerns cognitive ability. While some individuals with autism experience mental retardation, by definition a person with Asperger's Disorder cannot possess a "clinically significant" cognitive delay and most possess average to above average intelligence.

While motor difficulties are not a specific criteria for Asperger's, children with Asperger's Disorder frequently have motor skill delays and may appear clumsy or awkward.

Diagnosis

Diagnosis of Asperger's Disorder is on the increase, although it is unclear whether it is more prevalent or whether more professionals are detecting it. The symptoms for Asperger's Disorder are the same as those listed for autism in the DSM-IV; however, children with AS do not have delays in the area of communication and language. In fact, to be diagnosed with Asperger’s, a child must have normal language development as well as normal intelligence. The DSM-IV criteria for AS specifies that the individual must have "severe and sustained impairment in social interaction, and the development of restricted, repetitive patterns of behavior, interests and activities that must cause clinically significant impairment in social, occupational or other important areas of functioning."

The first step to diagnosis is an assessment, including a developmental history and observation. This should be done by medical professionals experienced with autism and other PDDs. If Asperger's Disorder or high-functioning autism is suspected, the diagnosis of autism will generally be ruled out first. Early diagnosis is also important as children with Asperger's Disorder who are diagnosed and treated early in life have an increased chance of being successful in school and eventually living independently. To learn more, see Consulting with Professionals.

Antidepressants Information


Antidepressants are medicines used to help people who have depression. Most people with depression get better with treatment that includes these medicines.

How do antidepressants work?
Most antidepressants are believed to work by slowing the removal of certain chemicals from the brain. These chemicals are called neurotransmitters. Neurotransmitters are needed for normal brain function. Antidepressants help people with depression by making these natural chemicals more available to the brain.

How long will I have to take an antidepressant?
Antidepressants are typically taken for at least 4 to 6 months. In some cases, patients and their doctors may decide that antidepressants are needed for a longer time.

What are the different kinds of antidepressants?
Antidepressants are put into groups based on which chemicals in the brain they affect. There are many different kinds of antidepressants, including:
Selective serotonin reuptake inhibitors (SSRIs)
citalopram (brand name: Celexa)
escitalopram (brand name: Lexapro)
fluoxetine (brand name: Prozac)
paroxetine (brand names: Paxil, Pexeva)
sertraline (brand name: Zoloft)
These medicines tend to have fewer side effects than other antidepressants. Some of the side effects that can be caused by SSRIs include dry mouth, nausea, nervousness, insomnia, sexual problems and headache.
Tricyclics
amitriptyline (brand name: Elavil)
desipramine (brand name: Norpramin)
imipramine (brand name: Tofranil)
nortriptyline (brand name: Aventyl, Pamelor)
Common side effects caused by these medicines include dry mouth, blurred vision, constipation, difficulty urinating, worsening of glaucoma, impaired thinking and tiredness. These antidepressants can also affect a person's blood pressure and heart rate.
Serotonin and norepinephrine reuptake inhibitors (SNRIs)
venlafaxine (brand name: Effexor)
duloxetine (brand name: Cymbalta)
Some common side effects caused by these medicines include nausea and loss of appetite, anxiety and nervousness, headache, insomnia and tiredness. Dry mouth, constipation, weight loss, sexual problems, increased heart rate and increased cholesterol levels can also occur.
Norepinephrine and dopamine reuptake inhibitors (NDRIs)
bupropion (brand name: Wellbutrin)
Some of the common side effects in people taking NDRIs include agitation, nausea, headache, loss of appetite and insomnia. It can also cause increase blood pressure in some people.
Combined reuptake inhibitors and receptor blockers
trazodone (brand name: Desyrel)
nefazodone (brand name: Serzone)
maprotiline
mirtazpine (brand name: Remeron)
Common side effects of these medicines are drowsiness, dry mouth, nausea and dizziness. If you have liver problems, you should not take nefazodone. If you have seizures, you should not take maprotiline.
Monamine oxidase inhibitors (MAOIs)
isocarboxazid (brand name: Marplan)
phenelzine (brand name: Nardil)
tranlcypromine (brand name: Parnate)
MAOIs are used less commonly than the other antidepressants. They can have serious side effects, including weakness, dizziness, headaches and trembling. Taking an MAOI antidepressant while you're taking another antidepressant or certain over-the-counter medicines for colds and flu can cause a dangerous reaction. Your doctor will also tell you what foods and alcoholic beverages you should avoid while you are taking an MAOI. You should not take an MAOI unless you clearly understand what medications and foods to avoid. If you are taking an MAOI and your doctor wants you to start taking one of the other antidepressants, he or she will have you stop taking the MAOI for a while before you start the new medicine. This gives the MAOI time to clear out of your body.

Will antidepressants affect my other medicines?
Antidepressants can have an effect on many other medicines. If you're going to take an antidepressant, tell your doctor about all the other medicines you take, including over-the-counter medicines and herbal health products (such as St. John's wort). Ask your doctor and pharmacist if any of your regular medicines can cause problems when combined with an antidepressant.

Source
Written by familydoctor.org editorial staff.

Sunday, June 15, 2008

Hypoglycemia Disease Information


Hypoglycemia, also called low blood sugar, occurs when your blood glucose (blood sugar) level drops too low to provide enough energy for your body's activities. In adults or children older than 10 years, hypoglycemia is uncommon except as a side effect of diabetes treatment, but it can result from other medications or diseases, hormone or enzyme deficiencies, or tumors.

Glucose, a form of sugar, is an important fuel for your body. Carbohydrates are the main dietary sources of glucose. Rice, potatoes, bread, tortillas, cereal, milk, fruit, and sweets are all carbohydrate-rich foods.

After a meal, glucose molecules are absorbed into your bloodstream and carried to the cells, where they are used for energy. Insulin, a hormone produced by your pancreas, helps glucose enter cells. If you take in more glucose than your body needs at the time, your body stores the extra glucose in your liver and muscles in a form called glycogen. Your body can use the stored glucose whenever it is needed for energy between meals. Extra glucose can also be converted to fat and stored in fat cells.

When blood glucose begins to fall, glucagon, another hormone produced by the pancreas, signals the liver to break down glycogen and release glucose, causing blood glucose levels to rise toward a normal level. If you have diabetes, this glucagon response to hypoglycemia may be impaired, making it harder for your glucose levels to return to the normal range.Symptoms

Symptoms of hypoglycemia include
hunger
nervousness and shakiness
perspiration
dizziness or light-headedness
sleepiness
confusion
difficulty speaking
feeling anxious or weak

Hypoglycemia can also happen while you are sleeping. You might
cry out or have nightmares
find that your pajamas or sheets are damp from perspiration
feel tired, irritable, or confused when you wake up

Hypoglycemia: A Side Effect of Diabetes Medications

Hypoglycemia can occur in people with diabetes who take certain medications to keep their blood glucose levels in control. Usually hypoglycemia is mild and can easily be treated by eating or drinking something with carbohydrate. But left untreated, hypoglycemia can lead to loss of consciousness. Although hypoglycemia can happen suddenly, it can usually be treated quickly, bringing your blood glucose level back to normal.
Causes of Hypoglycemia

In people taking certain blood-glucose lowering medications, blood glucose can fall too low for a number of reasons:
meals or snacks that are too small, delayed, or skipped

excessive doses of insulin or some diabetes medications, including sulfonylureas and meglitinides (Alpha-glucosidase inhibitors, biguanides, and thiazolidinediones alone should not cause hypoglycemia but can when used with other diabetes medicines.)

increased activity or exercise

excessive drinking of alcohol
Prevention

Your diabetes treatment plan is designed to match your medication dosage and schedule to your usual meals and activities. If you take insulin but then skip a meal, the insulin will still lower your blood glucose, but it will not find the food it is designed to break down. This mismatch might result in hypoglycemia.

To help prevent hypoglycemia, you should keep in mind several things:
Your diabetes medications. Some medications can cause hypoglycemia. Ask your health care provider if yours can. Also, always take medications and insulin in the recommended doses and at the recommended times.
What to Ask Your Doctor About Your Diabetes Medications
Could my diabetes medication cause hypoglycemia?

When should I take my diabetes medication?

How much should I take?

Should I keep taking my diabetes medication if I am sick?

Should I adjust my medication before exercise?


Your meal plan. Meet with a registered dietitian and agree on a meal plan that fits your preferences and lifestyle. Do your best to follow this meal plan most of the time. Eat regular meals, have enough food at each meal, and try not to skip meals or snacks.

Your daily activity. Talk to your health care team about whether you should have a snack or adjust your medication before sports or exercise. If you know that you will be more active than usual or will be doing something that is not part of your normal routine—shoveling snow, for example—consider having a snack first.

Alcoholic beverages. Drinking, especially on an empty stomach, can cause hypoglycemia, even a day or two later. If you drink an alcoholic beverage, always have a snack or meal at the same time.

Your diabetes management plan. Intensive diabetes management—keeping your blood glucose as close to the normal range as possible to prevent long-term complications—can increase the risk of hypoglycemia. If your goal is tight control, talk to your health care team about ways to prevent hypoglycemia and how best to treat it if it does occur.Normal and target blood glucose ranges (mg/dL)
Normal blood glucose levels in people who do not have diabetes
Upon waking (fasting) 70 to 110
After meals 70 to 140
Target blood glucose levels in people who have diabetes
Before meals 90 to 130
1 to 2 hours after the start of a meal less than 180
Hypoglycemia (low blood glucose) 70 or below

Treatment

If you think your blood glucose is too low, use a blood glucose meter to check your level. If it is 70 mg/dL or below, have one of these "quick fix" foods right away to raise your blood glucose:
2 or 3 glucose tablets
1/2 cup (4 ounces) of any fruit juice
1/2 cup (4 ounces) of a regular (not diet) soft drink
1 cup (8 ounces) of milk
5 or 6 pieces of hard candy
1 or 2 teaspoons of sugar or honey

After 15 minutes, check your blood glucose again to make sure that it is no longer too low. If it is still too low, have another serving. Repeat these steps until your blood glucose is at least 70. Then, if it will be an hour or more before your next meal, have a snack.

If you take insulin or a diabetes medication that can cause hypoglycemia, always carry one of the quick-fix foods with you. Wearing a medical identification bracelet or necklace is also a good idea.

Exercise can also cause hypoglycemia. Check your blood glucose before you exercise.

Severe hypoglycemia can cause you to lose consciousness. In these extreme cases when you lose consciousness and cannot eat, glucagon can be injected to quickly raise your blood glucose level. Ask your health care provider if having a glucagon kit at home and at work is appropriate for you. This is particularly important if you have type 1 diabetes. Your family, friends, and co-workers will need to be taught how to give you a glucagon injection in an emergency.

Prevention of hypoglycemia while you are driving a vehicle is especially important. Checking blood glucose frequently and snacking as needed to keep your blood glucose above 70 mg/dL will help prevent accidents.
Hypoglycemia and Diabetes: Doing Your Part

Signs and symptoms of hypoglycemia can vary from person to person. Get to know your own signs and describe them to your friends and family so they will be able to help you. If your child has diabetes, tell school staff about hypoglycemia and how to treat it.

If you experience hypoglycemia several times a week, call your health care provider. You may need a change in your treatment plan: less medication or a different medication, a new schedule for your insulin shots or medication, a different meal plan, or a new exercise plan.

Hypoglycemia in People Who Do Not Have Diabetes

Two types of hypoglycemia can occur in people who do not have diabetes: reactive (postprandial, or after meals) and fasting (postabsorptive). Reactive hypoglycemia is not usually related to any underlying disease; fasting hypoglycemia often is.
Symptoms

Symptoms of both types resemble the symptoms that people with diabetes and hypoglycemia experience: hunger, nervousness, perspiration, shakiness, dizziness, light-headedness, sleepiness, confusion, difficulty speaking, and feeling anxious or weak.

If you are diagnosed with hypoglycemia, your doctor will try to find the cause by using laboratory tests to measure blood glucose, insulin, and other chemicals that play a part in the body's use of energy.
Reactive Hypoglycemia

In reactive hypoglycemia, symptoms appear within 4 hours after you eat a meal.

Diagnosis
To diagnose reactive hypoglycemia, your doctor may
ask you about signs and symptoms

test your blood glucose while you are having symptoms (The doctor will take a blood sample from your arm and send it to a laboratory for analysis. A personal blood glucose monitor cannot be used to diagnose reactive hypoglycemia.)

check to see whether your symptoms ease after your blood glucose returns to 70 or above (after eating or drinking)

A blood glucose level of less than 70 mg/dL at the time of symptoms and relief after eating will confirm the diagnosis.

The oral glucose tolerance test is no longer used to diagnose hypoglycemia; experts now know that the test can actually trigger hypoglycemic symptoms.

Causes and Treatment
The causes of most cases of reactive hypoglycemia are still open to debate. Some researchers suggest that certain people may be more sensitive to the body's normal release of the hormone epinephrine, which causes many of the symptoms of hypoglycemia. Others believe that deficiencies in glucagon secretion might lead to hypoglycemia.

A few causes of reactive hypoglycemia are certain, but they are uncommon. Gastric (stomach) surgery, for instance, can cause hypoglycemia because of the rapid passage of food into the small intestine. Also, rare enzyme deficiencies diagnosed early in life, such as hereditary fructose intolerance, may cause reactive hypoglycemia.

To relieve reactive hypoglycemia, some health professionals recommend taking the following steps:
eat small meals and snacks about every 3 hours

exercise regularly

eat a variety of foods, including meat, poultry, fish, or nonmeat sources of protein; starchy foods such as whole-grain bread, rice, and potatoes; fruits; vegetables; and dairy products

choose high-fiber foods

avoid or limit foods high in sugar, especially on an empty stomach

Your doctor can refer you to a registered dietitian for personalized meal planning advice. Although some health professionals recommend a diet high in protein and low in carbohydrates, studies have not proven the effectiveness of this kind of diet for reactive hypoglycemia.
Fasting Hypoglycemia

Diagnosis
Fasting hypoglycemia is diagnosed from a blood sample that shows a blood glucose level of less than 50 mg/dL after an overnight fast, between meals, or after exercise.

Causes and Treatment
Causes include certain medications, alcohol, critical illnesses, hormonal deficiencies, some kinds of tumors, and certain conditions occurring in infancy and childhood.

Medications
Medications, including some used to treat diabetes, are the most common cause of hypoglycemia. Other medications that can cause hypoglycemia include
salicylates, including aspirin, when taken in large doses

sulfa medicines, which are used to treat infections

pentamidine, which treats a very serious kind of pneumonia

quinine, which is used to treat malaria

If using any of these medications causes your blood glucose to drop, your doctor may advise you to stop using the drug or change the dosage.

Alcohol
Drinking, especially binge drinking, can cause hypoglycemia because your body's breakdown of alcohol interferes with your liver's efforts to raise blood glucose. Hypoglycemia caused by excessive drinking can be very serious and even fatal.

Critical Illnesses
Some illnesses that affect the liver, heart, or kidneys can cause hypoglycemia. Sepsis (overwhelming infection) and starvation are other causes of hypoglycemia. In these cases, treatment targets the underlying cause.

Hormonal Deficiencies
Hormonal deficiencies may cause hypoglycemia in very young children, but usually not in adults. Shortages of cortisol, growth hormone, glucagon, or epinephrine can lead to fasting hypoglycemia. Laboratory tests for hormone levels will determine a diagnosis and treatment. Hormone replacement therapy may be advised.

Tumors
Insulinomas, insulin-producing tumors, can cause hypoglycemia by raising your insulin levels too high in relation to your blood glucose level. These tumors are very rare and do not normally spread to other parts of the body. Laboratory tests can pinpoint the exact cause. Treatment involves both short-term steps to correct the hypoglycemia and medical or surgical measures to remove the tumor.
Conditions Occurring in Infancy and Childhood

Children rarely develop hypoglycemia. If they do, causes may include
Brief intolerance to fasting, often in conjunction with an illness that disturbs regular eating patterns. Children usually outgrow this tendency by age 10.

Hyperinsulinism, which is the excessive production of insulin. This condition can result in transient neonatal hypoglycemia, which is common in infants of mothers with diabetes. Persistent hyperinsulinism in infants or children is a complex disorder that requires prompt evaluation and treatment by a specialist.

Enzyme deficiencies that affect carbohydrate metabolism. These deficiencies can interfere with the body's ability to process natural sugars, such as fructose and galactose, glycogen, or other metabolites.

Hormonal deficiencies such as lack of pituitary or adrenal hormones.

Hope through Research

The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) was established by Congress in 1950 as one of the National Institutes of Health under the U.S. Department of Health and Human Services. The NIDDK conducts and supports research in diabetes, glucose metabolism, and related conditions. Researchers supported by NIDDK are investigating topics such as
What are the causes of hypoglycemia?

Can islet cell transplantation eliminate hypoglycemia?

Can laparoscopy (a surgical procedure) be used to find and remove insulinomas (insulin-producing tumors)?

Do new frequent-glucose-monitoring devices help prevent hypoglycemia?

Why do repeated episodes of hypoglycemia lead to loss of awareness of hypoglycemia symptoms?

A complete listing of clinical research studies can be found at http://ClinicalTrials.gov on the Internet.

Points to Remember
Diabetes-Related Hypoglycemia
If you think your blood glucose is low, check it and treat the problem right away.

To treat hypoglycemia, have a serving of a quick-fix food, wait 15 minutes, and check your blood glucose. Repeat the treatment until your blood glucose is above 70.

Keep quick-fix foods in the car, at work—anywhere you spend time.

Be careful when you are driving. Check your blood glucose frequently and snack as needed to keep your level above 70 mg/dL.
Hypoglycemia Unrelated to Diabetes
In reactive hypoglycemia, symptoms occur within 4 hours of eating. People with this condition are usually advised to follow a healthy eating plan recommended by a registered dietitian.

Fasting hypoglycemia can be caused by certain medications, critical illnesses, hereditary enzyme or hormonal deficiencies, and some kinds of tumors. Treatment targets the underlying problem.

For More Information

American Diabetes Association
National Service Center
1701 North Beauregard Street
Alexandria, VA 22311
Phone: 1–800–232–3472
Fax: 703–549–6995
Email: customerservice@diabetes.org
Internet: www.diabetes.org

Juvenile Diabetes Research Foundation International
120 Wall Street
19th Floor
New York, NY 10005–4001
Phone: 1–800–533–2873 or 212–785–9500
Fax: 212–785–9595
Email: info@jdrf.org
Internet: www.jdrf.org

Rickets Disease Information


Rickets is a bone problem that usually occurs in children. Rickets can make your child's bones hurt. The bones soften and can break easily.

What causes rickets?
Most cases of rickets are caused by a lack of vitamin D, but rickets can also be inherited. Vitamin D helps the bones absorb calcium and phosphorus from food. When your child does not get enough vitamin D, his or her bones do not get those necessary nutrients that makes bones strong.

Children ages 6-24 months are at the highest risk of rickets because their bones are growing very rapidly during this period. Your child may also be at risk if he or she:
Has dark skin
Doesn't get moderate exposure to sunlight
Wears sunscreen at all times when outside
Doesn't eat foods containing vitamin D
Breastfeeds without a vitamin D supplements
What are the symptoms of rickets?
The image below shows what some of the symptoms of rickets look like.


How can the doctor tell if my child has rickets?
Your doctor will ask about your family health history and your child's health and diet. Your child will need a full physical exam. Blood tests and x-rays of the arms or legs can also help your doctor determine if your child has rickets.

How is rickets treated?
Treatment depends on the type of rickets your child has. Nutritional rickets is treated with vitamin D and calcium, and often improvements occur within a few weeks of treatment. If your child has inherited rickets or has an illness causing the problem, you may need to see a doctor who specializes in rickets.


How can I keep my child from getting nutritional rickets?
Be sure your child gets enough vitamin D and calcium. If you breastfeed your baby, your doctor will prescribe a vitamin supplement that includes vitamin D (because human milk only has a small amount of vitamin D). If your baby gets less than 16 ounces of formula per day, he or she will need extra vitamin D.

Your doctor can also help you determine if your older child needs more vitamin D or calcium. Your doctor will also tell you about how much time in the sun is safe for your child. However, it is important to remember that infants and babies should be protected from direct sunlight. To make sure your child is getting enough vitamin D, you should make sure your older child eats foods that are high in calcium, such as milk, cheese, and salad greens.

Source

Written by familydoctor.org editorial staff.

Wilson's disease Information


Wilson's disease is an inherited disorder that causes too much copper to accumulate in your liver, brain and other vital organs. Wilson's disease shows up in a variety of different ways, but the disease can remain silent for years.

Copper plays a key role in the development of healthy nerves, bones, collagen and the skin pigment melanin. Normally, copper is absorbed from your food, and any excess is excreted through bile — a substance produced in your liver.

But in people with Wilson's disease, copper isn't eliminated properly and instead accumulates, possibly to a life-threatening level. Left untreated, Wilson's disease is fatal. When diagnosed early, Wilson's disease is treatable, and many people with the disorder live normal lives.
Signs and symptoms

In people with Wilson's disease, copper begins accumulating in the liver immediately after birth, but signs and symptoms rarely occur before the age of 5 or 6. The disease almost always becomes apparent before age 30, but Wilson's disease symptoms sometimes appear much later in life.

The stored copper can damage many organs and tissues, but the liver and central nervous system are most often affected:
Liver problems. Because copper first accumulates in the liver, most people initially have signs of liver damage, including abdominal pain and yellowing of the skin and whites of the eyes (jaundice). Later in the disease, anemia or the vomiting of blood can occur. Sometimes the disease progresses without any obvious symptoms until you develop cirrhosis — irreversible scarring of the liver that affects its ability to carry out vital functions. At this point, signs and symptoms may include swelling in your abdomen (ascites) or legs (edema) and an enlarged spleen.
Neurological problems. Up to about one-third of people with Wilson's disease have neurological signs and symptoms, such as tremors, muscle spasms, unsteady walk, difficulty speaking and drooling.
Behavioral or psychological problems. Wilson's disease can cause abrupt personality changes and inappropriate behavior. Children with the disease are sometimes misdiagnosed as having behavioral problems because they behave erratically or perform poorly in school.
Eye, kidney and bone problems. Many people with Wilson's disease, even those who don't have other signs and symptoms, develop a distinctive, golden brown pigmentation around their corneas (Kayser-Fleischer ring). Caused by copper deposits, Kayser-Fleischer rings are often discovered during a routine eye exam. Wilson's disease can also interfere with the kidneys' filtering function and lead to weak, brittle bones (osteoporosis). The disease can also lead to kidney stones.
Causes

A number of foods, especially liver, shellfish, nuts, avocados and mushrooms, contain abundant amounts of copper. When you eat copper-containing foods, the copper is absorbed by your small intestine, bound to circulating proteins in your blood and delivered to your liver. Any copper your body doesn't use is carried away by bile, a substance produced in your liver that helps digest fats.

Gene defect causes copper buildup
In Wilson's disease, a genetic mutation of chromosome 13 affects ATP7B, a protein that helps transport copper into the bile. ATP7B is also involved in incorporating copper into ceruloplasmin, a protein that carries the mineral through your bloodstream. The defects in the ATP7B gene mean that copper isn't eliminated properly, and instead builds up in your liver, where it can cause serious and sometimes irreversible damage. In time, excess copper spills out of your liver and begins accumulating in and harming other organs, especially your brain, eyes, kidneys and joints.

Although some ATP7B mutations occur spontaneously, most are passed from one generation to the next. Wilson's disease is inherited as an autosomal recessive trait, which means that to develop the disease you must inherit two copies of the defective gene, one from each parent. If you receive only one abnormal gene, you won't become ill yourself, but you're considered a carrier and can pass the gene to your children. Wilson's disease itself is rare, but as many as one in 100 people has one defective ATP7B gene.
Risk factors

If both parents are carriers of one abnormal Wilson's gene, they have a 25 percent chance of having a child with two normal genes, a 50 percent chance of having a child who also is a carrier, and a 25 percent chance of having a child with two recessive genes who will develop the disease. These chances are the same in each pregnancy.

For that reason, experts recommend that all children and siblings of people with Wilson's be tested for the disease. In addition, your doctor may want to test you if you had a parent or grandparent who died of unexplained liver disease.
When to seek medical advice

It may be years and sometimes decades before signs and symptoms of Wilson's disease appear. If you do have signs of the disease — difficulty speaking, problems with balance, tremors in your arms and hands, abdominal pain or yellowing of your skin — see your doctor right away. These same problems can result from other conditions, many of them more common than Wilson's disease, and a medical evaluation can help determine the exact cause.
Screening and diagnosis

Diagnosing Wilson's disease can be challenging for several reasons. First, symptoms of Wilson's disease are often indistinguishable from those of hepatitis, alcoholic cirrhosis and other chronic liver diseases. What's more, many symptoms may evolve over time, rather than appearing all at once. Behavioral changes that come on gradually can be especially hard to link to Wilson's. Finally, no single test — not even genetic tests — can diagnose Wilson's by itself. As a result, doctors rely on a combination of symptoms and test results to make the diagnosis. Some of the tests commonly used include:
Blood and urine tests. Your doctor is likely to measure the amount of ceruloplasmin and copper in your blood and to test the amount of copper excreted in your urine in a 24-hour period.
Eye exam. Using a microscope with a high-intensity light source (slit lamp), an ophthalmologist checks your eyes for Kayser-Fleischer rings.
Liver biopsy. In this procedure, a small sample of tissue is removed from your liver and examined in a laboratory for excess copper. Your doctor may use a thin needle or a small, lighted instrument (laparoscope) to obtain the sample. Needle or laparoscopic biopsies are relatively minor procedures requiring only local anesthesia. Risks include bleeding and infection.
Genetic tests. Because more than 200 mutations of ATP7B exist, researchers haven't been able to develop a simple genetic test that can help screen or diagnose Wilson's disease in the general population. But a procedure called haplotype analysis can identify people within a single family who may have inherited the disorder.
Complications

Wilson's disease can increase your risk of bone fractures and of serious infections and may greatly impair kidney function. But one of the most serious complications is liver damage, which may be so severe that only a liver transplant can prolong life. If not treated, Wilson's disease is fatal.

Other complications may include:
Damage to the central nervous system. This may cause uncontrollable repetitive movements, stiffness, speech problems, and the loss of the ability to function at work or at home. Coordination also may be affected, resulting in clumsiness and awkwardness in mobility.
Psychological problems. The most common psychological complications associated with Wilson's disease include mood swings, depression, inappropriate behavior, agitation, loss of memory and confusion — problems that sometimes may be mistaken for signs of Alzheimer's disease.
Treatment

The goal of Wilson's disease treatment is twofold:
To remove excess copper
To prevent copper from building up again

Once treatment starts, the disease stops progressing and many signs and symptoms improve. But some problems may take time to resolve. Other problems — especially liver scarring and certain neurological or psychological symptoms — may not be completely reversible. Untreated Wilson's disease is always fatal.

Doctors usually prescribe one of the following medications to help treat Wilson's disease:

Penicillamine (Cuprimine, Depen). Chelation therapy is the use of chemicals to bind to and remove metals and minerals. Penicillamine was the first copper chelating drug approved for use in Wilson's disease. It works by binding to copper and creating a water-soluble complex that's excreted in your urine. Although it's an effective treatment, penicillamine can cause serious side effects, including skin problems, bone marrow suppression, worsening of neurological symptoms and birth defects.

Penicillamine shouldn't be taken by people with kidney disease or those who are allergic to penicillin. If you do chose to be treated with the drug, you'll also need to take vitamin B-6 supplements because penicillamine can cause a serious deficiency of this vitamin.
Trientine (Syprine). Another chelating agent, trientine also binds to copper and helps eliminate it from your body. Because it's less toxic than penicillamine, many doctors consider it a first-line therapy, especially in people with liver or neurological symptoms. Trientine also binds to iron, and taking iron supplements can reduce the drug's effectiveness.

Zinc acetate. Working differently from chelating drugs, the mineral zinc helps prevent copper from being absorbed in your stomach and small intestine. Zinc has few side effects, but it's slower acting than are penicillamine and trientine and so is usually considered an initial treatment only for pregnant women, for people without symptoms or liver damage, or for those who can't tolerate stronger medications.

Doctors may switch people taking penicillamine or trientine to zinc once their symptoms improve, or zinc may be used in combination with penicillamine for people with neurological symptoms.
Tetrathiomolybdate. This copper-binding agent is being studied in clinical trials.

If you have Wilson's disease, you'll need to continue taking a copper-reducing medication for life. Your doctor may also recommend that you avoid tap water containing more than 100 micrograms of copper per liter, copper-containing vitamin and mineral supplements, and foods high in copper such as:
Liver
Shellfish
Mushrooms
Nuts
Chocolate
Dried fruit
Dried peas, beans and lentils
Avocados
Bran products

Liver transplantation
For people with severe cirrhosis, fulminating hepatitis or other serious liver disorders, a liver transplant may be the only option.

By Mayo Clinic Staff
Sep 19, 2007

Wednesday, June 11, 2008

Smoking Information


People have many questions about tobacco that can sometimes be hard to answer. They include questions about tobacco, including cigarettes, cigars, spit and other types of smokeless tobacco, and other tobacco products; nicotine; addiction; and quitting. Many of those questions are answered here. Here we also talk about how smoking and tobacco can affect a person's health, including the heart, circulation, and lungs, its effect on unborn babies, and how it affects the development of cancer and other diseases.

Is there a safe way to smoke cigarettes?

No. All cigarettes can damage the human body. Any smoking is dangerous. Cigarettes are the only legal product whose advertised and intended use -- smoking -- is harmful to the body and causes cancer.

Although some people try to make their smoking habit safer by smoking fewer cigarettes, most smokers find that hard to do. Research has found that even smoking as few as 1 to 4 cigarettes a day can lead to serious health outcomes, including an increased risk of heart disease and a higher risk of dying at a younger age.

Some people think that switching from high-tar and high-nicotine cigarettes to those with low tar and nicotine makes smoking safer, but this is not true. When people switch to brands with lower tar and nicotine, they often end up smoking more cigarettes, or more of each cigarette, to get the same nicotine dose as before.

Smokers have been led to believe that "light" cigarettes have a lower health risk and are a good option to quitting. This is not true. A low-tar cigarette can be just as harmful as a high-tar cigarette because a person often takes deeper puffs, puffs more often, or smokes them to a shorter butt length. Studies have not found that the risk of lung cancer is any lower in smokers of "light" or low-tar cigarettes.

Hand-rolled cigarettes, while reported to be a cheaper and healthier way to smoke, are not safer than commercial brands. In fact, lifelong smokers of hand-rolled cigarettes have been found to have an increased risk of cancers of the larynx (voice box), esophagus (tube that connects the mouth to the stomach), mouth, and pharynx (throat) when compared with smokers of manufactured cigarettes.

"All natural" cigarettes are marketed as having no chemicals or additives and rolled with 100% cotton filters. There is no proof they are healthier or safer than other cigarettes, nor is there good reason to think they would be. Smoke from these cigarettes, like the smoke from all cigarettes, contains many carcinogens (agents that cause cancer) and toxins that come from the tobacco itself, including tar and carbon monoxide.

Herbal cigarettes, even though they do not contain tobacco, also give off tar and carbon monoxide and are dangerous to your health. The bottom line is there's no such thing as a safe smoke.

Is cigarette smoking really addictive?

Yes. The nicotine in cigarette smoke causes an addiction to smoking. Nicotine is an addictive drug (just like heroin and cocaine) for 3 main reasons.
When taken in small amounts, nicotine creates pleasant feelings that make the smoker want to smoke more.
Smokers usually become dependent on nicotine and suffer physical and emotional (psychological) withdrawal symptoms when they stop smoking. These symptoms include nervousness, headaches, and trouble sleeping.
Because nicotine affects the chemistry of the brain and central nervous system, it can affect the mood and nature of the smoker.

What does nicotine do?

In large doses nicotine is a poison and can kill by stopping a person's breathing muscles. Smokers usually take in small amounts that the body can quickly break down and get rid of. The first dose of nicotine makes a person to feel awake and alert, while later doses produce a calm, relaxed feeling.

Nicotine can make new smokers, and regular smokers who get too much of it, feel dizzy or sick to their stomachs. The resting heart rate for young smokers increases 2 to 3 beats per minute. Nicotine also lowers skin temperature and reduces blood flow in the legs and feet. It may play a role in increasing smokers' risk of heart disease and stroke.

Many people mistakenly think that nicotine is the substance in tobacco that causes cancer. This belief may cause some people to avoid using nicotine replacement therapy when trying to quit. Although nicotine is what gets (and keeps) people addicted to tobacco, other substances in tobacco are responsible for its cancer-causing effects. There is some early evidence from lab-based studies that nicotine may help existing tumors to grow, but whether these results apply to people is not yet known and more research is needed.

Why do people begin to smoke?

Most people begin smoking as teens, usually because of curiosity and peer pressure. People with friends and/or parents who smoke are more likely to take up smoking than those who don't.

The tobacco industry's ads and other promotions for its products are another big influence in our society. The tobacco industry spends billions of dollars each year to create and market ads that show smoking as an exciting, glamorous, and healthy adult activity.

Who is most likely to become addicted?

Anyone who starts smoking is at risk of becoming addicted to nicotine. Studies show that cigarette smoking is most likely to become a habit during the teen years. The younger a person is when he or she begins to smoke, the more likely he or she is to develop nicotine addiction. Almost 90% of adult smokers started at or before age 19.

How many people smoke cigarettes?

Among adults in the United States, cigarette smoking has declined from about 42% of the population in 1965 to about 20.9% in 2005 (the latest year for which numbers are available). About 45 million adults currently smoke cigarettes. About 23.9% of men and 18.1% of women were smokers. Education seems to affect smoking rates, as shown by a steady decrease in the smoking rates in groups with a higher level of education.

Is smoking common among young people?

Yes. Tobacco use, including smoking cigarettes, using chew or spit tobacco, and dipping snuff, is common among American youth, according to the most recent government surveys.

Despite declines in recent years, about 1 in 3 male high school students (32%) and 1 in 4 female high school students (25%) used some type of tobacco in 2005. More than 1 in 5 students (23%) were considered current cigarette smokers. Over half of these students (about 55%) reported they had tried to quit smoking during the past year. Cigar smoking was also common among high school students (about 14%).

Also, about 12% of middle school students used some form of tobacco, with cigarettes (8%) being the most common.

Tobacco use is higher among male students for all products except cigarettes, where the numbers for boys and girls are now about the same.

Other problems have been linked to smoking. Studies have shown that students who smoke are more likely to use other drugs, get in fights, carry weapons, attempt suicide, and engage in high-risk sexual behaviors.

What in cigarette smoke is harmful?

Cigarette smoke is a complex mixture of chemicals produced by the burning of tobacco and the additives. The smoke contains tar, which is made up of more than 4,000 chemicals, including over 60 known to cause cancer. Some of these substances cause heart and lung diseases, and all of them can be deadly. You might be surprised to know some of the chemicals found in cigarette smoke. They include:
cyanide
benzene
formaldehyde
methanol (wood alcohol)
acetylene (the fuel used in welding torches)
ammonia

Cigarette smoke also contains the poisonous gases nitrogen oxide and carbon monoxide. The active ingredient that produces the effect people are looking for is nicotine, an addictive drug.

Does smoking cause cancer?

Yes. Tobacco use accounts for about one- third of all cancer deaths in the United States. Smoking causes about 87% of lung cancer deaths. Smoking also causes cancers of the larynx (voice box), mouth, pharynx (throat), esophagus (swallowing tube), and bladder, and contributes to the development of cancers of the pancreas, cervix, kidney, and stomach. It is also linked to the development of some types of leukemia. Cigars, pipes, and spit and other types of smokeless tobacco all cause cancers, too. There is no safe way to use tobacco.

How does cigarette smoke affect the lungs?

Damage to the lungs begins early in smokers, and all cigarette smokers have a lower level of lung function than non-smokers. This continues to worsen as long as the person smokes. Cigarette smoking causes many lung diseases that can be just as dangerous as lung cancer.

Chronic Bronchitis

Chronic bronchitis is a disease where the airways produce too much mucus, forcing the smoker to cough it out. It is a common problem for smokers. The lungs start to produce large amounts of mucus more and more of the time. The airways become inflamed (swollen) and the cough becomes chronic -- it doesn't get better or go away. Airways get blocked by scars and mucus. Serious infections can also result.

Emphysema

Cigarette smoking is also the major cause of emphysema -- a disease that slowly destroys a person's ability to breathe. Oxygen reaches the blood by moving across a large surface area in the lungs. Normally, thousands of tiny sacs make up this surface area. With emphysema, the walls between the sacs break down and create larger but fewer sacs. This decreases the lung surface area, which lowers the amount of oxygen reaching the blood. Over time, the lung surface area can become so small that a person with emphysema often must gasp for breath.

Shortness of breath (especially when lying down), a chronic mild cough (which is often dismissed as "smoker's cough"), feeling tired, and sometimes weight loss are early signs of emphysema. People with emphysema are at risk for many other problems linked to weak lung function, including pneumonia. In later stages of the disease, patients can only breathe comfortably with the help of an oxygen tube under the nose. Emphysema cannot be reversed, but it can be slowed down -- especially if the person stops smoking.

Chronic Obstructive Pulmonary Disease

More than 7 million current and former smokers suffer from chronic obstructive pulmonary disease (COPD), the name used to describe both chronic bronchitis and emphysema. COPD is the fourth leading cause of death in America. More women die from COPD than men. Smoking is the main risk factor for COPD. About 80% to 90% of COPD deaths are caused by smoking. The late stage of chronic lung disease is one of the most miserable of all medical conditions. It creates a feeling of gasping for breath all the time -- much like the feeling of drowning.

Why do smokers have "smoker's cough?"

Cigarette smoke has chemicals that irritate the air passages and lungs. When a smoker inhales these substances, the body tries to protect itself by making mucus and coughing. The early morning smokers cough happens for many reasons. Normally, tiny hair-like formations (called cilia) beat outward and sweep harmful material out of the lungs. Cigarette smoke slows the sweeping action, so some of the poisons in the smoke stays in the lungs and mucus stays in the airways. While a smoker sleeps, some cilia recover and begin working again. After waking up, the smoker coughs because the lungs are trying to clear away the poisons that built up the previous day. The cilia will completely stop working after they have been exposed to smoke for a long time. Then the smoker's lungs are even more exposed and susceptible than before, especially to bacteria and viruses in the air.

If you smoke but don't inhale, is there any danger?

Yes. Wherever smoke touches living cells, it does harm. Even if smokers don't inhale they are breathing the smoke as secondhand smoke and are still at risk for lung cancer. Pipe and cigar smokers, who often don’t inhale, are at an increased risk for lip, mouth, tongue, and some other cancers.

Does cigarette smoking affect your heart?

Yes. Smoking cigarettes increases the risk of heart disease, which is the number one cause of death in the United States. Smoking, high blood pressure, high cholesterol, physical inactivity, obesity, and diabetes are all risk factors for heart disease, but cigarette smoking is the biggest risk factor for sudden death from a heart attack. Smokers who have a heart attack are more likely to die within an hour of the heart attack than non-smokers. Cigarette smoke can harm the heart at very low levels, even when the amount is too low to cause lung disease.

How does smoking affect pregnant women and their babies?

Pregnant women who smoke risk the health and lives of their unborn babies. Smoking during pregnancy is linked with a greater chance of miscarriage, premature delivery, stillbirth, infant death, low birth-weight, and sudden infant death syndrome (SIDS). Up to 5% of infant deaths would be prevented if pregnant women did not smoke.

When a pregnant woman smokes, she's smoking for two. The nicotine, carbon monoxide, and other harmful chemicals enter her bloodstream, pass directly into the baby's body, and keep it from getting vital nutrients and oxygen it needs for growth.

Breast-feeding is a good way to feed a new baby, but if the mother smokes it exposes the baby to nicotine and other poisons in the smoke through breast milk. Nicotine could cause many unwanted symptoms in the baby, such as restlessness, a rapid heartbeat, vomiting, or diarrhea.

Some research has also suggested that children whose mothers smoked while pregnant or who have been exposed to secondhand smoke, even in small amounts, may be slower learners in school. They may be shorter and smaller than children of non-smokers. They are also more likely to smoke when they get older.

What are some of the short- and long-term effects of smoking cigarettes?

Smoking causes many types of cancer, which may not develop for years. But cancers account for only about half of the deaths linked to smoking. Long-term, smoking is also a major cause of heart disease, aneurysms, bronchitis, emphysema, and stroke, and it makes pneumonia and asthma worse. Wounds take longer to heal and the immune system may be less effective in smokers than in non-smokers. Smoking also damages the arteries. Because of this, many vascular surgeons refuse to operate on patients with peripheral artery disease (poor blood circulation in the arms and legs) unless they stop smoking. And male smokers have a higher risk of sexual impotence (erectile dysfunction) the longer they smoke

The truth is that cigarette smokers die younger than non-smokers. In fact, according to a study from the Centers for Disease Control and Prevention (CDC) done in the late 1990s, smoking shortened male smokers' lives by 13.2 years and female smokers' lives by 14.5 years. Men and women who smoke are much more likely to die during middle age (between the ages of 35 and 69) than those who have never smoked.

Smoking also causes many short-term effects, such as poor lung function. Because of this, smokers often suffer shortness of breath and nagging coughs. They often will tire easily during physical activity. Some other common short-term effects include less ability to smell and taste, premature aging of the skin, bad breath, and stained teeth

What are the chances that smoking will kill you?

About half of all the people who continue to smoke will die because of the habit. In the United States, tobacco causes nearly 1 in 5 deaths, killing about 440,000 Americans each year. Smoking is the single most preventable cause of death in our society.

Based on current patterns, smoking will kill about 650 million people alive in the world today. If these patterns continue, tobacco-caused deaths worldwide are expected to increase from about 5 million per year today to about 10 million per year by the 2030s. Most of these deaths will happen in developing countries.

What are the dangers of environmental tobacco smoke?

Environmental tobacco smoke (ETS), also known as passive smoking or secondhand smoke, occurs when non-smokers breathe in other people’s tobacco smoke. This includes mainstream smoke (smoke that is inhaled and then exhaled into the air by smokers) and sidestream smoke (smoke that comes directly from the burning tobacco in cigarettes). ETS contains the same harmful chemicals as the smoke that smokers inhale. In fact, because sidestream smoke is formed at lower temperatures, it has even larger amounts of some toxic and cancer-causing substances than mainstream smoke.

There is strong evidence that ETS causes serious damage to human health. ETS causes about 3,000 lung cancer deaths and about 35,000 deaths from heart disease each year in healthy non-smokers who live with smokers. It can also affect non-smokers by causing asthma and other respiratory problems, eye irritation, headaches, nausea, and dizziness. Children whose parents smoke are more likely to suffer from asthma, pneumonia, bronchitis, ear infections, coughing, wheezing, and increased mucus production. Babies of parents who smoke have a greater chance of dying of sudden infant death syndrome (SIDS). Pregnant women exposed to ETS are at risk for having a low birth weight baby and may also be at risk for pre-term delivery and miscarriage.

Breast Cancer

An issue that continues to be an active focus of scientific research is whether secondhand smoke may increase the risk of breast cancer. Both mainstream and secondhand smoke have about 20 chemicals that, in high concentrations, cause breast cancer in rodents. Chemicals in tobacco smoke reach breast tissue and are found in breast milk.

The evidence about secondhand smoke and breast cancer risk in human studies is controversial, at least in part because the risk has not been shown to be increased in active smokers. One possible explanation for this is that tobacco smoke may have different effects on breast cancer risk in smokers and in those who are just exposed to smoke.

A report from the California Environmental Protection Agency in 2005 concluded that the evidence regarding secondhand smoke and breast cancer is "consistent with a causal association" in younger, mainly premenopausal women. The 2006 US Surgeon General's report, The Health Consequences of Involuntary Exposure to Tobacco Smoke, concluded that there is "suggestive but not sufficient" evidence of a link at this point. In any case, women should be told that this possible link to breast cancer is yet another reason to avoid contact with secondhand smoke.

Am I at risk for getting lung cancer from smoke odors on clothing or from being in a room where people have been smoking?

There are no reports in the medical literature of research on the cancer-causing effects of cigarette odors, but the literature shows that secondhand smoke can seep into hair, clothing, and other surfaces. The unknown cancer-causing effects would probably be minimal compared to direct secondhand smoke exposure, such as living in a household that has a smoker.

What is being done to protect people from the hazards of smoking?

Tobacco Labels

Both the public and private sectors have acted to help decrease smoking-related deaths and illnesses in this country. Since 1966, the US Surgeon General's health warnings have been required on all cigarette packages and, since 1987, on all spit or oral tobacco products. Since 2001, the 7 major cigar manufacturers in the United States have provided 5 health warnings that rotate on cigar labels. These labels are much like those on cigarette packages.

Advertising

Congress banned cigarette advertising on TV and radio in 1971 and spit tobacco advertising in 1987. The American Legacy Foundation and many states have made anti-smoking public service messages that are featured on television, radio, and billboards.

Taxes

Taxes on cigarettes have risen in many states in recent years. They have been shown to discourage young people from starting to smoke and to encourage smokers to quit. State taxes on tobacco vary from as low as 7 cents (in South Carolina) to up to $2.58 a pack (in New Jersey).

Smoking Bans

Laws in all 50 states and the District of Columbia restrict or do not allow smoking in certain public places. These laws range from simple restrictions, such as designated areas in government buildings, to laws that ban smoking in all public places and workplaces. Many federal worksites, including the White House, are smoke-free. Smoking is also banned on all domestic airplane flights.

Are menthol cigarettes safer than other brands?

Menthol cigarettes are not safer than any other brand. In fact, they may even be more dangerous. About one-fourth of all cigarettes sold in the United States are flavored with menthol. These cigarettes are especially popular among African Americans. The added menthol produces a cooling sensation in the throat when the smoke is inhaled. It also decreases the cough reflex and covers the dry feeling in the throat that smokers often have. People who smoke menthol cigarettes can inhale deeper and hold the smoke in longer.

A recent study showed that people who smoke menthol cigarettes are less likely to try to quit and are less likely to be successful when they do try. This study proposed that menthol smokers might want to switch to non-menthol cigarettes before trying to quit in order to improve their chances of quitting smoking.

Are spit tobacco and snuff safe alternatives to cigarette smoking?

There are many terms used to describe tobacco that is put in the mouth , such as spit, oral, smokeless, chewing, and snuff tobacco. The use of any kind of spit or smokeless tobacco is a major health risk. It is a less lethal substitute for smoking cigarettes but, less lethal is a far cry from safe.

The amount of nicotine absorbed is usually more than the amount delivered by a cigarette. Overall, people who dip or chew get about the same amount of nicotine as regular smokers. The most harmful cancer-causing substances in spit tobacco are tobacco-specific nitrosamines which have been found at levels 100 times higher than the nitrosamines that are allowed in bacon, beer, and other foods. These carcinogens cause lung cancer in experimental animals, even when injected, not inhaled.

The juice from the smokeless tobacco is absorbed directly through the lining of the mouth. This causes sores and white patches (called leukoplakia) that often lead to cancer of the mouth.

People who use spit and other types of smokeless tobacco greatly increase their risk of other cancers including those of the pharynx (throat). Other effects of spit tobacco use include chronic bad breath, stained teeth and fillings, gum disease, tooth decay, tooth loss, tooth abrasion, and loss of bone in the jaw. Users may also have problems with high blood pressure and may be at increased risk for heart disease.

What is snus? Is it safe?

Snus (sounds like "snoose") is a type of moist snuff first used in Sweden. It is often flavored with spices or fruit, and is usually packaged in thin bags much like tea bags. It is also sold loose, as a moist powder. Like snuff and other spit tobaccos, snus is held between the gum and mouth tissues where the juice is absorbed into the body.

Because it is heated during processing, Swedish snus has fewer tobacco-specific nitrosamines (see previous question) that are known to cause cancer. Snus users in Sweden have lower rates of several types of cancer than Swedish smokers. Because of this, some people believe snus is "safe." However, snus users have a higher risk of cancer of the pancreas than non-users. They also get sores or spots in the mouth (lesions) where the snus is held. It appears that snus users may have mouth cancer more often than non-users, though more study needs to be done to confirm this.

Since US tobacco sellers are not required to list what is in their products, it would be hard to know how the US versions of snus might compare to the Swedish versions without doing studies here. Since snus has just been introduced, it is uncertain what other problems it might cause.but, snus is not a safe alternative to smoking.

What are the health risks of smoking pipes or cigars?

Many people view cigar smoking as more "civilized" and "sophisticated," as well as less dangerous than cigarette smoking. Yet a single large cigar can contain as much tobacco as an entire pack of cigarettes.

Most of the same cancer-causing substances found in cigarettes are found in cigars. Most cigars have as much nicotine as several cigarettes. When cigar smokers inhale, nicotine is absorbed as quickly as it is with cigarettes. For those who do not inhale, it is absorbed more slowly through the lining of the mouth. Both inhaled and non-inhaled nicotine are highly addictive.

Smoking cigars causes cancers of the lung, oral cavity (lip, tongue, mouth, throat), larynx (voice box), esophagus (swallowing tube), and probably cancers of the bladder and pancreas. Cigar smokers have a greater risk of dying from cancer of the mouth, larynx, or esophagus than non-smokers. The risk of death from lung cancer is not as high as it is for cigarette smokers, but is still many times higher than the risk for non-smokers.

Cigar smokers who inhale deeply and smoke several cigars a day are also at increased risk for heart disease and chronic lung disease.

Pipe smokers have an increased risk of dying from cancers of the lung, throat, esophagus, larynx, pancreas, and colon and rectum. They also have an increased risk of dying of heart disease, stroke, and chronic lung disease. The level of these risks seems to be about the same as that for cigar smokers.

Smoking cigars or pipes is not a safe alternative to smoking cigarettes.

What about more "exotic" forms of smoking tobacco, such as clove cigarettes, bidis, and hookahs?

Many forms of flavored tobacco have become popular in recent years, especially among younger people. Clove cigarettes (kreteks), bidis, and, more recently, hookahs, often appeal to those who want something a little different. They also give young people another way to experiment with tobacco. The false image of these products as clean, natural, and safer than regular cigarettes seems to attract some young people who may otherwise not start smoking. But these products carry many of the same risks of cigarettes and other tobacco products and each has its own additional problems linked to it.

Clove Cigarettes

Clove cigarettes, also called kreteks, are imported mainly from Indonesia and contain 60% to 70% tobacco and 30% to 40% ground cloves, clove oil, and other additives. The chemicals in cloves have been linked to asthma and other lung diseases.

Users often have the mistaken notion that smoking clove cigarettes is a safe alternative to smoking tobacco. But they are a tobacco product with the same health risks as cigarettes. In fact, they have been shown to deliver more nicotine, carbon monoxide, and tar than regular cigarettes.

Bidis

Bidis or "beedies" are flavored cigarettes imported mainly from India. They are hand-rolled in an unprocessed tobacco leaf and tied with colorful strings on the ends. Their popularity has grown in recent years in part because they come in many candy-like flavors such as strawberry, vanilla, and grape, they usually cost less than regular cigarettes, and they often give the smoker an immediate buzz.

Even though bidis contain less tobacco than regular cigarettes, they deliver higher levels of nicotine (the addictive chemical in tobacco) and other harmful substances such as tar and carbon monoxide. Because they are thinner than regular cigarettes, they require about 3 times as many puffs per cigarette. They are also unfiltered. Bidis appear to have all of the same health risks of regular cigarettes, if not more. Bidi smokers have much higher risks of heart attacks, chronic bronchitis, and some cancers than non-smokers.

Hookah

Hookah (or narghile) smoking, started in the Middle East, Users burn flavored tobacco (called shisha) in a water pipe and inhale the smoke through a long hose. It has recently become popular among young people, especially around college campuses. Hookah smoking is usually a social event that allows the smokers to spend time together and talk as they pass the pipe around. It is marketed as being a safe alternative to cigarettes because the percentage of tobacco in the product smoked is low. This claim for safety is false. The water does not filter out many of the toxins. In fact, hookah smoke contains more toxins such as nicotine, carbon monoxide, tar, and other hazardous substances than cigarette smoke. Several types of cancer have been linked to hookah smoking. Hookah use is also linked to other unique risks not linked with cigarette smoking. For example, infectious diseases can be spread by sharing the pipe or through the way the tobacco is prepared.

All forms of tobacco are dangerous. Even if the health risks were smaller for some tobacco products as opposed to others, all tobacco products contain nicotine, which can lead to increased use and addiction. Tobacco cannot be considered safe in any amount or form.

What can I do to help with any damage that may have occurred because of smoking?

If you have used tobacco in any form, now or in the past, tell your health care provider so he or she can be sure that you have appropriate preventive health care. It is well known that tobacco use puts you at risk for certain health-related illnesses. This means part of your health care should focus on related screening and preventive measures to help you stay as healthy as possible. For example, you will want to be sure that you regularly check the inside of your mouth for any changes and have an oral exam by your doctor or dentist if you find any changes or problems. The American Cancer Society recommends that periodic check-ups should include oral cavity (mouth) exams. By doing this tobacco users may be able to find oral changes and leukoplakia (white patches on the mouth membranes) early. This may help prevent oral cancer.

You should also be aware of any of the following:


any change in a cough (for example, you cough up more mucus than usual)

a new cough

coughing up blood

hoarseness

trouble breathing

wheezing

headaches

chest pain

loss of appetite

weight loss

general fatigue (feeling tired all the time)

repeated respiratory infections


Any of these could be signs of lung cancer or a number of other lung conditions and you should report any symptom to your doctor as soon as possible. Although these can be signs of a problem, many lung cancers do not cause any noticeable symptoms until they are advanced and have spread to other parts of the body.

Remember that tobacco users have an increased risk for other cancers too, depending on the way they use tobacco. You can learn more about the types of cancer you may be at risk for by reading the American Cancer Society document that discusses the way you use tobacco (i.e., Cigar Smoking). Other risk factors for these cancers may be more important than your use of tobacco, but you should know the additional risks that might apply to you.

If you have any health concerns that may be related to your tobacco use, please see your health care provider as soon as possible. Taking care of yourself and getting treatment for small problems will give you the best chance for successful treatment. The best way, though, to take care of yourself and decrease your risk for life-threatening lung problems is to quit using tobacco.

How does tobacco use affect the economy?

The tobacco industry is one of the most profitable businesses in the country, making billions of dollars every year. But the costs of smoking are far higher than the income from cigarette sales.


Smoking causes more than $167 billion each year in health-related costs, including the cost of lost productivity caused by deaths from smoking.

Smoking-related medical costs totaled more than $75.5 billion in 1998 and accounted for 8% of personal health care medical expenditures.

Death-related productivity losses from smoking among workers cost the US economy more than $92 billion yearly (average for 1997-2001).

For each pack of cigarettes sold in 1999, $3.45 was spent on medical care caused by smoking, and $3.73 lost in productivity, for a total cost to society of $7.18 per pack.


Can quitting really help a lifelong smoker?

Yes. It is never too late to quit using tobacco. The sooner smokers quit, the more they can reduce their chances of getting cancer and other diseases. Within minutes of smoking the last cigarette, the body begins to restore itself.

20 minutes After Quitting
Your heart rate and blood pressure drop.
(Effect of Smoking on Arterial Stiffness and Pulse Pressure Amplification, Mahmud, A, Feely, J. 2003. Hypertension:41:183.)

12 hours After Quitting
The carbon monoxide level in your blood drops to normal.
(US Surgeon General's Report, 1988, p. 202)

2 weeks to 3 Months After Quitting
Your circulation improves and your lung function increases.
(US Surgeon General's Report, 1990, pp.193, 194,196, 285, 323)

1 to 9 Months After Quitting
Coughing and shortness of breath decrease; cilia (tiny hair-like structures that move mucus out of the lungs) regain normal function in the lungs, increasing the ability to handle mucus, clean the lungs, and reduce the risk of infection.
(US Surgeon General's Report, 1990, pp. 285-287, 304)

1 Year After Quitting
The excess risk of coronary heart disease is half that of a smoker's.
(US Surgeon General's Report, 1990, p. vi)

5 Years After Quitting
Your stroke risk is reduced to that of a non-smoker 5 to 15 years after quitting.
(US Surgeon General's Report, 1990, p. vi)

10 Years After Quitting
The lung cancer death rate is about half that of a continuing smoker's. The risk of cancer of the mouth, throat, esophagus, bladder, cervix, and pancreas decreases.
(US Surgeon General's Report, 1990, pp. vi, 131, 148, 152, 155, 164,166)

15 Years After Quitting
The risk of coronary heart disease is that of a non-smoker's.
(US Surgeon General's Report, 1990, p. vi)

Are there some benefits of quitting that I'll notice right away?

Kicking the tobacco habit offers some benefits that you'll notice right away and some that will develop slowly over time. These benefits can improve your day-to-day life a lot.


Food will taste better.

Your sense of smell returns to normal.

Your breath, hair, and clothes smell better.

Your teeth and fingernails stop yellowing.

Ordinary activities no longer leave you out of breath (for example, climbing stairs or doing light housework).

Quitting also helps stop the damaging effects of tobacco on how you look, including premature wrinkling of your skin and gum disease.

Suppose I smoke for a while and then quit?

Smoking begins to cause damage right away and is highly addictive. Some studies have found nicotine to be as addictive as heroin, cocaine, or alcohol. It’s the most common form of drug addiction in the United States. It’s much better to never start smoking cigarettes -- and become addicted to nicotine -- than it is to smoke with the thought of quitting later. Like alcohol, heroin, and cocaine, nicotine creates a tolerance in the body. This makes it hard to quit, but with the right support it can be done.

When an ex-smoker smokes a cigarette, even years after quitting, the body reacts in the same way as it did when the person was smoking, which can cause the person to want to smoke again. Don't think you can smoke for a short while and quit when you want to; it's seldom that easy.

How do people quit smoking?

Quitting smoking is not easy, and some people try many times before succeeding. There are many ways to quit smoking. For example, some have been successful by stopping "cold turkey," by taking part in the Great American Smokeout®, or by using other methods.

There's no single best way to quit. Quitting for good may mean using many methods, including step-by-step manuals, self-help classes or counseling, toll-free telephone-based counseling programs, and/or using medicines like nicotine replacement therapies (see next question). Smokers may also need to make changes in their daily routine to help them break their smoking habits.

What are nicotine replacement therapies?

Nicotine replacement therapies (NRTs) are medicines that help decrease or stop a smoker's withdrawal symptoms by giving controlled doses of nicotine without the other harmful chemicals of cigarette smoke. NRTs are available as patches, gums, inhalers, nasal sprays, or lozenges. The Food and Drug Administration (FDA) has approved all of these products to help people quit smoking. Patches, gums, and lozenges are available over-the-counter, but you will need a doctor’s prescription for inhalers and nasal sprays.

These products work by helping smokers control their physical responses as they quit. For best results, smokers should use NRTs along with behavioral change programs that are designed to help smokers break their psychological (mental) dependence on cigarettes. For more information on such programs, call the American Cancer Society at 1-800-ACS-2345.

Not everyone can use nicotine replacement therapy. People with certain medical conditions and pregnant women should use it only with a doctor's supervision. It is always a good idea to get your doctor's input and support when you decide to quit smoking.

The best time to start NRT is when you begin to try to quit. Many smokers ask if it is possible to start a program of nicotine replacement while you are still smoking. There is some research on smokers using NRT while still smoking, but the results are still too early to say for certain if this is dangerous to your health. The most important thing is to make sure that you are not overdosing on nicotine, which can affect your heart and blood circulation. It is safest to be under a doctor's care if you wish to try smoking and using NRT while you are tapering cigarette smoking.

For more information, see the American Cancer Society document, Guide to Quitting Smoking.

Are there other medicines or vaccines to help smokers quit?

Yes. Some medicines that don't have nicotine have already been approved to help with quitting smoking.

Bupropion (Zyban®), was first used as an antidepressant, and later approved by the FDA to help people quit smoking. This medicine does not contain nicotine and is available only with a doctor's prescription. It affects chemicals in the brain that are related to nicotine craving. It can be used alone or together with nicotine replacement.

Newer medicines may help smokers (or former smokers) by stopping them from getting physical pleasure from smoking. The medicines seem to work by stopping nicotine from stimulating the brain, either by blocking the brain receptors that nicotine normally attaches to, or preventing it from reaching the brain altogether (as in the case of the vaccines -- see below).

One such medicine, varenicline (Chantix®), is FDA-approved for help with quitting. Varenicline is a pill taken twice a day. Once in the body, it attaches to nicotine receptors in the brain, reducing the pleasurable effects of smoking and helping to reduce nicotine withdrawal symptoms. Many studies have shown varenicline can more than double the chances of quitting smoking. Because varenicline is a newer drug, there is no research supporting its safety in using it with nicotine replacement products at the same time.

Other medicines still being studied include rimonabant, which is also a pill, and vaccines that are given as a series of injections. Early tests of these new treatments have been promising. They seem to be safe, and may help some smokers quit or stay quitters. But larger studies are needed to show these treatments are effective before the FDA can approve them for use. Many large studies of these treatments are now under way. If they prove effective, one or more of these drugs could be approved within the next few years.

It is not likely that any one of these drugs will work in every person, however, and using different quitting aids at the same time is still the best way to increase your chances of success. For more information on quitting and medicines that can be used, see Guide to Quitting Smoking.

Where can I go for help?

It is hard to stop smoking, but you can do it! About 45.7 million Americans have quit smoking for good, and now there are more former smokers than current smokers. Many organizations offer information, counseling, and other services on how to quit, as well as information on where to go for help. Other good resources for finding help include your doctor, dentist, local hospital, or employer.

If you want to quit smoking and need help, contact one of the following organizations:

American Cancer Society
Telephone: 1-800-ACS-2345 (1-800-227-2345)
Internet address: http://www.cancer.org

American Heart Association
Telephone: 1-800-AHA-USA-1 (1-800-242-8721)
Internet address: www.amhrt.org

American Lung Association
Telephone: 1-800-586-4872 (1-800-LUNG-USA)
Internet address: www.lungusa.org

National Cancer Institute
Cancer Information Service
Telephone: 1-800-4-CANCER (1-800-422-6237)
Internet address: www.cancer.gov

Centers for Disease Control and Prevention
Office on Smoking & Health
Internet address: www.cdc.gov/tobacco

Smokefree.gov
(Info on state telephone-based counseling programs)
Telephone: 1-800-QUITNOW (1-800-784-8669)
Internet Address: www.smokefree.gov

Additional Resources

More Information From Your American Cancer Society

The following information may also be helpful to you. These materials may be ordered from our toll-free number, 1-800-ACS-2345 (1-800-227-2345).
Child and Teen Tobacco Use (also available in Spanish)

Cigar Smoking (also available in Spanish)

Cigarette Smoking (also available in Spanish)

Double Your Chances of Quitting Smoking

Guide to Quitting Smoking (also available in Spanish)

Helping a Smoker Quit: Dos and Don'ts

Quitting Smoking - Help for Cravings and Tough Situations (also available in Spanish)

Secondhand Smoke (also available in Spanish)

Women and Smoking (also available in Spanish)

References

American Cancer Society. Cancer Facts & Figures 2008. Atlanta, GA: American Cancer Society; 2008.

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